Regina Mamou has a research-based practice that focuses on the desire to understand the diversity of ideological systems. Her work is an amalgamation of fact and fiction, placing historical information together with falsehood to explore the power of belief systems, especially as it relates to communism and totalitarianism. This interest stems from her familial background where she grew up with the awareness of the implications of political ideology intertwined with religion. Mamou's mother, who is Polish-American, and Mamou's father, who is a Christian-Chaldean from Iraq, raised her multiculturally. As a former priest, Mamou's father left the clergy, and Iraq, for fear of persecution. For this reason, she is interested in not only the examination of social utopias but also the struggle to create community through a dystopian future.